Mice can be bred under the following conditions: Monogamous pairs in a "standard" mouse cage. Institutions using mice for scientific purposes are responsible for meeting recommendations of the institution’s Animal Ethics Committee to ensure that facilities for the housing and care of mice are appropriate to the maintenance of well­being and health of the mice. No. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Fighting among adult male mice is a well-documented behavior and can result in severe wounding and death. Authorization for Animal Housing and Special Services Costs. Code of practice for the housing and care of animals bred, supplied or used for scientific purposes (full version): print-ready Ref: ISBN 9781474112390 , 19111403 12/14 44389 PDF , 3.42MB , 227 pages ACUO is a unit of the U-M Office of Research: ULAM is a unit of the Medical School Office of Research: Copy Generated on: January 25, 2021, 5:38 am, Guidelines for Documenting Scientific Justification for Exceeding Cage Densities, Maximum Housing Densities for Rat and Mouse Cages, Guidelines on Anesthesia and Analgesia in Ruminants, Guidelines on Administration of Substances to Laboratory Animals, Guidelines on Use of Streptozotocin in Rodents, Guidelines on Adjuvant Use in Rabbits Rats and Mice, The Regents of the University of Michigan. stream Animal Care & Use Office (ACUO) Nursing mothers or breeding pairs are kept in a quiet cage or tub with no wire floor. Trio breeding SOP with local performance measures to house mice in solid bottom cages with 71 in2 floor space. Not a departure. However, the thermoneutral zone of mice is between 26°C and 34°C (79–93°F) and therefore they may experience cold stress in the laboratory unless nesting material is provided for them to regulate their body temperature and the microclimate … The IACUC acknowledges that some specialized genetically modified lines may require more than 2 adults and 1 litter in the breeding cage to facilitate adequate production. 䍫�����Q1Md:UdVDJ��*� Some strains are more aggressive than others, and fight regardless of the age at combination. Code of Practice for the Housing and Care of Laboratory Mice Rats Guinea Pigs. OpenURL . Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. When possible (depending on the caging system used) individually housed mice should be provided housing that allows visual, auditory and olfactory contact with other mice. Phone: (734) 764-0277 The normal total cholesterol level is 26.0-82.4 mg/dl. %���� Q�N���e9k��DjϋY�O��� �!�=� the draft guidelines for the housing of mice in scientific institutions. Typical husbandry conditions in our institution allow housing a maximum of 5 mice per cage and changing bedding every 2 wk within an SPF barrier facility. The design of animal housing should facilitate well being of the animals, meet research requirements, minimise experimental variables, and isolate the animals from wide variations in temperature and humidity and from vibration and sources of loud noise. Delayed weaning (weaning at >21 days) requires prior IACUC approval. Justification for housing situations that fall outside of the normal must be approved in the IACUC animal use protocol. Guidelines for the housing of mice in scientific institutions (PDF|3.8 MB) Guidelines for the housing of guinea pigs in scientific institutions (PDF|309.3 KB) Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. CCAC guidelines: Mice 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. Guidelines for the Social Housing and Environmental Enrichment of Laboratory Rodents and Rabbits The University of Texas at Austin . Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. Ann Arbor, MI 48109 This code is made under the Prevention of Cruelty to Animals Act 1986 and applies to all institutions breeding and using such animals for research, testing and teaching.. This does not apply to: Littermates that have been cage mates since birth. However, attempts to assess the effectiveness of specific pathogen-free (SPF 1) housing, husbandry, and health care have been sparse. According to UK Home Office guidelines, the room temperature for mice should be 20–24°C (68–75°F) and kept as stable as possible . The same authors ( Smith et al. the draft guidelines for the housing of mice in scientific institutions. Males from different litters can be combined within seven days of weaning, only if age difference is 7 days apart or less. Limiting breeding cage occupancy reduces the incidence of morbidity and mortality due to overcrowding. ��~[Q\ �]*{��~��A���WFŀ�̥-��g|��ۢ����j�i�a,}�w�s�4W�-n��~zU�'��];��"�~]#P r�ݶ4{׈˝h�g�(�Y�6�5��b���CV�B ����5��^'�6�1�� �O��͒\a�4��D`H�ȸ�F��\��2S�X,?>۲�Ȓݾõ��A���h@U$QY�������� New arrival mice. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. Instead, the author would cite animal housing guidelines such as those made available by their own institutions or by the NIH. These rodents are social species and should be housed together, unless scientifically justified for individual housing. GUIDELINES FOR RATS AND MICE . Additional floor space may be required in order to ensure animal well-being. Canadian Council on Animal Care. Enclosures designed to cause minimum disturbance to the animals. Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design Debby Laukens, ... the genetic history of mutant mice is often ambiguous when mice are shared between institutions (Sellers et al. Mild to moderate wounds (those involving minimal damage to the epidermis) necessitates consultation with ULAM veterinary personnel for determination of appropriate therapy. 14 - 1 March 1999 Guidelines for the Care and Housing of Dogs in Scientific Institutions Animal Welfare Unit, NSW Agriculture, Locked Bag 21, Orange NSW 2800 Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9264 9533 Fax (02) 9264 9632 3 1. 1 0 obj With a physical land area of just over 700 square kilometers and a population of around 5.4 million people, this densely populated island has abundant tropical flora, parks, and g… Questions or concerns about the content of this document should be directed to the Unit for Laboratory Animal Medicine (ULAM) at (734) 764-0277 or ulam-questions@umich.edu. 2005 ) extended this study design with other mouse strains (young adult male and female BALB/cJ, NOD/LtJ, and FVB/NJ mice) to evaluate optimal housing densities. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). No. However, rats and mice are social animals; and individual housing constitutes a stressful situation. 2 0 obj These breeding strategies are only allowable provided that pregnant females are separated prior to parturition and only 1 litter of pups with up to 2 adults remain in the cage after pups are born. The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. Institutional Animal Care and Use Committee . in. GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS (2012) Cached. Group-house weaned males with their littermates only. It is suggested that the housing of laboratory rodents … The need for genotyping leads to the requirement to identify very young mice, thus creating specific problems (...) Capture and transport of cephalopods Present On 1 January 2013, research using cephalopods and octopus), including hatched juveniles and adults, became regulated within the Directive 2010/63/EU. Guidelines for Housing Capacity. Investigators must submit a BUworks Internal Service Request (ISR) for per diems and for special service charges prior to placing animal orders. Fax: (734) 936-3235 The NC3Rs have led a data crowdsourcing project, which estimated the prevalence of aggression in UK facilities as approximately 15 in every 1,000 mice. endobj Current guidelines recommend housing mice in social groups as they are highly social animals, however, aggression and fighting can occur between group-housed males leading to injuries and potentially death. The Code of Practice for Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits applies throughout Victoria. Cage sizes recommended in current European guidelines on accommodation for laboratory animals are preferably based on scientific evidence, but where this is lacking or insufficient, recommendations are also based on best practice. Many experimental approaches require housing rodents in individual cages, including in epilepsy research. The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). Breeding trios (one male, two females) in a 100 sq. Email: ulam-questions@umich.edu. Code of practice for the housing and care of. Follow procedures outlined in. National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Basic requirements for good rodent housing and husbandry are given in the table below. <> Provides guidance on best practice standards for housing animals based on published scientific information and practices employed in New South Wales, Australia. 8,9 Indeed, many studies have compared individual versus group housing of rodents under laboratory conditions. 3.5. For infectious experiments, mice are transferred to a designated biosafety level 2 facility and usually are … Purpose. SCIENTIFIC PURPOSES I - HOUSING AND CARE THE UNIVERSITIES FEDERATION FOR ANIMAL WELFARE ' "A: GUIDELINES ON THE CARE OF LABORATORY ANIMALS AND THEIR USE FOR SCIENTIFIC PURPOSES I. The National Research Council (NRC) “Guide for the Care and Use of Laboratory Animals” (2011) provides recommended minimum housing space expectations for laboratory rats and mice (p.57). The primary objective of this code is to establish minimum standards and promote recommendations for the housing and care of … Exceptions to this guideline require prior IACUC approval. Unit for Laboratory Animal Medicine (ULAM) Many murine pathogens are known to result in immune perturbations that can affect research outcomes (Hsu, et al., 2016; Macy, et al., 2011). Although a strain is considered stable when backcrossed for 10 generations, original 129 genes that are too close to the mutated gene to be segregated by … no extended weaning is allowed if post-partum estrus is used. Modifications of cages for mice usually consist of providing material for nest building and structures which can serve as hiding places and/or for climbing. ARRP Guideline 20: Guidelines for the Housing of Rats in Scientific Institutions Animal Welfare Branch, NSW Department of Primary Industries, Locked Bag 21, Orange NSW 2800. Canadian Council on Animal Care. See Guidelines for Documenting Scientific Justification for Exceeding Cage Densities for details on required data. This is Part 3.2 of the Code of Practice for the Housing and Care of Laboratory Mice, Rats, Guinea Pigs and Rabbits. A.L Hargreaves. The caging choices for conventionally housed mice were filter-topped shoebox cages (81%), open cages (52%), and ventilated caging systems (48%). Keyphrases. Guidelines for the Housing of Rabbits in Scientific Institutions, NSW Animal Research Review Panel. Management of Fighting Mice . Email: acuoffice@umich.edu, HUSBANDRY & VETERINARY CARE It is questionable whether conventional housing systems for rodents such as mice, rats and guinea-pigs meet this demand. House males individually in these circumstances, or with females, if intending to breed. 3 0 obj To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). endobj … While we have successfully managed many mouse colonies over the years using this system, we are uncertain that the cage space guidelines described in the 8th edition of the Guide allows trio-breeding schemes in standard cages. Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. (Enclosures should allow for a minimum floor area of 250cm2 for a single housed mouse, a minimum floor area of 500cm2 for two mice and ensuring a minimum floor area of 60cm2 per additional adult mouse when mice are housed in larger groups.) The . Housing for Laboratory Rats, Mice, Guinea pigs and Rabbits. Guidelines for Transgenic Research. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to The total cholesterol content of mice measured after 14 days of maintenance in the four study groups. endobj 412 Victor Vaughan If post-partum estrus is used in "standard" mouse cages, the first litter must be weaned by 21 days of age to prevent the presence of two litters in a cage, i.e. %PDF-1.5 Effect of the Extract on the Intestinal Transit of Charcoal Meal in Mice. <>>> Ventilated cages were designed to prevent the accumulation of NH )و�z�Ҡ�lcc�։7�޵����k�%� PP$rT��k�aK6m�B�B9&MV�����Z8�oWָ.�)^�>wjAВLt�ܵ�+:Rt {C1%�9p. Housing in stable, compatible groups - it is important to take into account sex, age, reproductive condition, familiarity, prior group housing experience when grouping the animals. We have reviewed 40 studies carried out between 1987 and 2000, in which preferences as well as the effect of housing modifications have been studied. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 <> For many protocols there may be no impact as the methods already being used are compliant with the 2020 Guidelines. Forty-one percent of institutions reported housing 0-20% of their mice under conventional conditions. Guidelines for Transgenic Research. Find the maximum number of rats and mice that can be house in each cage in the Rodent Cage Capacity Policy. These rodents are social species and should be housed together, unless scientifically justified for individual housing. It is suggested that the housing of laboratory rodents should be improved by the use of … Pages 83. Download Links [www.animalethics.org.au] ... BibTeX @MISC{12guidelinesfor, author = {}, title = {GUIDELINES FOR THE HOUSING OF MICE IN SCIENTIFIC INSTITUTIONS}, year = {2012}} Share. • If scientifically justified in an approved IACUC protocol, mice may be individually housed in specific situations outlined in the IACUC protocol. Ann Arbor, MI 48109 animals for scientific purposes. Phone: (734) 763-8028 8 Epizootic diarrhea of infant mice virus (EDIM) is commonly used as a generic name for all mouse rotaviruses. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> given to mice infected with human-pathogenic or zoonotic agents or genetically modified mice that har-bour receptors for human pathogens. Abstract. An exception to a Policy must be described and justified in the Animal Protocol and approved by the full IACUC at a convened monthly meeting. 2012). GUIDANCE & OVERSIGHT To ensure reproducibility and reduce variability, institutions have moved toward housing mice in barrier facilities and maintaining colonies in a specific pathogen-free (SPF) status. if housed in standard #3 rat caging. Rats can be bred in the following conditions: Separate male before parturition if caging is <212 square inches, e.g. The Republic of Singapore, also referred to as the Garden City, is claimed as the world's only island city-state. x��Zmo�� ���'X+�(�X�$�w[����i��[���Z>EN����BR�m�B�=G���yy晡��o����_n?݉��Z��݊��db�ry���E�đ1�OQ��,uTj�e2�Z,�]^\}�V�k-������[!�����(�2���,U�Tf�LYb*�Ab,��Ϗ�����?�����O�NGq�t)���,_����/�ٮ�����|���~l�5Ic\Px��be��@�jjD�4��b��tDHRFI6E�"�$$���ڮŬ�.��e>"1�"��w`�t&~���v;_���j����m.�l9_�Y��ŬCf��H�P��Z��.ӨH�����'�>��z��b.��_������#�T����Qm���!��n�4+���}�'j��L���}�I�(K���m��>�P��䈛�"�5�)⥋��m������}P�1?��?���Ͽ����{�7:�@"a�,Gl��P�h���U���(�JT��H=�XN���(/�H��T�2��|�H9Ud�D��$2�(2-e�؈���V �@��$>�`wݻA� Deviation from Guide should statement according to IACUC-approved: Scientific justification Use a clean cage when combining males from different litters to prevent territorial behavior. ANZCCART 2000 New arrival mice. cage ("standard" rat cage). Guideline No. The NACLAR Guidelines set out the responsibilities of all the parties involved in the care and use of animals for scientific purposes, in accordance with widely accepted scientific, ethical and legal principles. The CCAC guidelines: Mice provides information for investigators, animal care committees, facility manag- Title: Guidelines for the Housing of Rats in Scientific Institutions Author: NSW Department of Primary Industries Created Date: 1/24/2008 1:20:25 PM To address the health and well-being of mice and rats by ensuring safe breeding practices and population densities. Guidelines on the Care and Use of Animals for Scientific Purposes, which has been developed by theNational Advisory Committee For Laboratory Animal Research (NACLAR), is a national guide which establishes the best practices in the use and care of animals for scientific purposes. The most common breeding scheme for mice at our AAALAC accredited institution is trio-breeding. Fax: (734) 936-3234 The NACLAR Guidelines set out the responsibilities of Tumour The keeping of experimental animals requires housing systems appropriate to the needs and behaviour of each species, as demanded by various supranational and national guidelines. Housing of Social Species (Policy) Policy: The IACUC has provided a set of guidance documents (Policies, Guidelines, and Informational Sheets) for use when planning animal procedures at the University of Iowa. Wean pups by 21 days of age in either breeding scheme. Mouse rotavirus (MRV) is a group A rotavirus that replicates in the villus epithelial cells of the small intestine. Deviation from Guide should statement according to a locally established performance standard. 28, 29 Using our strategy, we have been able to group-house as many as 10 castrated mice, in a large rat cage with enrichment materials, in harmonious social conditions. In general, the housing temperature for laboratory mice in research facilities is between 20–26 °C [6, 7] or 18–23 °C ; while the thermoneutral … This review should begin no later than October 1, 2020. There is no doubt that the housing conditions have a robust influence on the behavior and physiology of laboratory mice. Code of Practice for the Housing and Care of Animals Bred, Supplied or Used for Scientific Purposes Contents 4.15 Specific requirements of breeding animals 79 Section 3, Chapter 2: Mice, rats, gerbils, hamsters and guinea pigs 80 1 Advice applicable to all rodents 80 1.1 Environmental conditions 80 1.2 Health 81 1.3 Housing, enrichment and care 81 Both cases require work in higher biosafety level containments, additional screening methods and special guidelines for the handling and restraint of such animals. To minimize fighting, the following group-housing practices are followed for mice: Do not combine adult male mice (older than 5 weeks). HOUSING AND CARE preprint issued by THE ROYAL SOCIETY 6 Carlton House Terrace, London SWlY SAG and UNIVERSITIES FEDERATION FOR ANIMAL WELFARE 8 Hamilton Close, South … Whilst we appreciate the efforts made by individuals to improve the living conditions of those animals unfortunate enough to be used in research, AAHR feels it would be inappropriate to comment on a system that we consider to be scientifically flawed and are fundamentally opposed to. 4 0 obj Ph (02) 6391 3682 Fax (02) 6391 3570 or Sydney Office Ph (02) 9872 0570 Fax (02) 9871 6938. Therefore, it is unclear why housing many laboratory mice (>4), instead of one-or-two per cage, with the improper use/reporting of clustered-data statistics, abound in the literature. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 … OLAW FAQ G10, Guide pp 6-7. 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