endstream Roscoe B. Jackson was a one-time head of the Hudson Motor Company who helped provide the funds for the first laboratory building at the property and the first five years of operation.) Watch Video. BMC Neurosci 2:11. endobj Variation in susceptibility to atherosclerosis among inbred strains of mice. Taconic's B6 Provides Superior Performance. C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Am J Physiol Lung Cell Mol Physiol 285(1):L32-42, Zhu W; Gilmour MI. Hear Res 112(1-2):216-34, Petkov PM; Ding Y; Cassell MA; Zhang W; Wagner G; Sargent EE; Asquith S; Crew V; Johnson KA; Robinson P; Scott VE; Wiles MV. This deletion results in the absence of the NNT protein, and is associated with impaired glucose homeostasis control and reduced insulin secretion. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation. x�%�A�@�}O�(��'.�r�^���� Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Quantities: Volume pricing is automatically applied when a minimum quantity per strain for a shipment is reached PMID: 11591219 C57BL/6J Genomic DNA from The Jackson Laboratory Wild-type Snca C57BL/6NCrl Mice from Charles River, Margate, UK Wild-type Snca This strain is the most well characterized, the first to have its’ entire genome sequenced, and is the genetic background strai . One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. The Genome of C57BL/6J “Eve”, the Mother of the Laboratory Mouse Genome Reference Strain. The C57BL/6J inbred strain was created by Dr. CC Little from the mating of female 57 with male 52 from Miss Abbie Lathrop's stock. 24 0 obj .. All mice were backcrossed and maintained at C57BL/6 background and housed in the special pathogen-free facilities. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. Mice belong to the Euarchontoglires clade, which includes humans. In the second cross (congenic cross), ... Petko M. Petkov, The Jackson Laboratory, Bar Harbor, Maine 04609, USA; LGC, Unit 1 - 2 Trident Industrial Estate, Pindar Road, Hoddesdon, Herts EN11 0WZ, UK Application note GAPP-0002. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genetic polymorphisms among C57BL/6 mouse inbred strains. (2)The Jackson Laboratory, Bar Harbor, ME, USA. <>stream Hybrid mice, such as B6C3, a cross between C57BL/6J females (B6) and C3H/HeJ males (C3), is gaining popularity. Diabetes 55(7):2153-6, Hollyfield JG; Bonilha VL; Rayborn ME; Yang X; Shadrach KG; Lu L; Ufret RL; Salomon RG; Perez VL. NSG™ Mice Pub Alert (Monthly): Course and Workshop Announcements (Monthly): Research Roundup (Biweekly): Cancer: Immunology, Inflammation & Autoimmunity: Immuno-oncology: Infect Immunogenetics 61(3):199-207, Zurita E; Chagoyen M; Cantero M; Alonso R; Gonzalez-Neira A; Lopez-Jimenez A; Lopez-Moreno JA; Landel CP; Benitez J; Pazos F; Montoliu L. 2011. Our mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Readily available in any quantity needed. The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. x�+� � | Five of the ten differences would cause amino acid changes. Mice Male B6.129S7-Rag1tm1Mom/J (B6.Rag1−/−) mice were directly imported from the Jackson Laboratory in 2009 and kept strictly in-bred in pathogen-free individually ventilated cage housing in our animal facility. Neuroscience 122(2):551-61, Mekada K; Abe K; Murakami A; Nakamura S; Nakata H; Moriwaki K; Obata Y; Yoshiki A. Hear Res 93(1-2):181-7, Ewart SL; Kuperman D; Schadt E; Tankersley C; Grupe A; Shubitowski DM; Peltz G; Wills-Karp M. 2000. C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. Adobe PDF Library 15.0; modified using iText 4.2.0 by 1T3XT endobj endobj 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m These mice are deficient in PSEN1. They are available as JAX MMRRC Stock# 034832 (formerly as Jackson Lab Stock# 005864). • J: Labor Code The Jackson Laboratory Dieser Stamm wurde nicht durch Rückkreuzungen, sondern durch Verpaaren von drei individuellen congenen Stämmen erzeugt, die die varianten Allele bereits auf einem C57BL/6J genetischen Hintergrund trugen: B6.C-Igh a immunoglobulin heavy chain complex B6.PL-Thy1 a thymus cell antigen 1, theta 1991. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. A naturally occurring deletion in nicotinamide nucleotide transhydrogenase (Nnt) exons 7-11 occurred in C57BL/6J sometime prior to 1984. x�S�*�*T0T0 B�����i������ yn) The Mx1r allele occurs only in strains A2G, SL/NiA, and T9, the latter being a strain derived from an influenza-resistant wild stock, and CAST/Ei, derived from Mus musculus castaneus. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. 2009. Enter your email if you are happy for us to connect and reachout to you with more questions. Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Watch this video to learn the importance of the C57BL/6 inbred mouse (B6), the most commonly used research strain. 2002. Macrophages from this strain are resistant to the effects of anthrax lethal toxin.Study-ready aged C57BL/6J males and females between 25 - 90 weeks of age available for order. 5 SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. J Immunol 129(4):1530-3, Smith BK; Andrews PK; West DB. The Jackson Laboratory b6 sjl ptprca pepcb boyj mice B6 Sjl Ptprca Pepcb Boyj Mice, supplied by The Jackson Laboratory, used in various techniques. x�S�*�*T0T0 B�����i������ yS& endobj The same cross gave rise to the C57L and C57BR strains. J Am Assoc Lab Anim Sci 55(4):375-86, Paigen B. J Lipid Res 36(7):1522-32, Kumar V; Kim K; Joseph C; Kourrich S; Yoo SH; Huang HC; Vitaterna MH; de Villena FP; Churchill G; Bonci A; Takahashi JS. Bioz Stars score: 92/100, based on 1 PubMed citations. 1998. This C-to-T transition, the T variant of SNP rs46447118, found in C57BL/6J and C57BL/6JEiJ but not any of the other 18 inbred strains tested, is in nucleotide 50 in the stem of the T loop and impairs maturation, leading to accumulation of a 105 nucleotide pre-tRNA band with leader and trailer sequences instead of the usual 115 nucleotide pre-tRNA, and also diminishes aminoacylation of this isodecoder. 2020-02-18T09:32:19-08:00 One of the unique advantages to working with mice, rather than other experimental organisms, is the availability of standard strains such as C57BL/6 (abbreviated B6), BALB/c, and many others that are used in thousands of laboratories around the world each year. <>stream Genome Biol 14(7):R82, Toye AA; Lippiat JD; Proks P; Shimomura K; Bentley L; Hugill A; Mijat V; Goldsworthy M; Moir L; Haynes A; Quarterman J; Freeman HC; Ashcroft FM; Cox RD. 13 0 obj It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. The following inbred strains are homozygous for the recessive QTL, Micrl. 18 0 obj This widely used … C57BL/6J (B6), B6.C-H-2bm12/KhEg (bm12), and C57BL/6J ApoE knockout (B6ApoE-/-) mice were originally obtained from The Jackson Laboratory (Bar Harbor, ME).B6ApoE-/-mice were backcrossed to C57BL/6J-lpr/lpr (B6/lpr) for four generations, and to MRL/MpJ-Fas lpr (MRL/lpr) for ten generations. In addi-tion, detailed behavioral observations were made of the males. Bioz Stars score: 89/100, based on 47 PubMed citations. This allele contains a stretch of 17,814 bp missing between exons 6 and 12. The Jackson Laboratory (JAX)® advocates adherence to the mouse strain nomenclature guidelines as described by the International Committee on Standardized Genetic Nomenclature for Mice. / FASEB J 14(7):871-6, Rossmeisl M; Rim JS; Koza RA; Kozak LP. Genotyping The assays used partially purified DNA as described in Paigen et al. Others have subsequently identified further SNP differences between sublines of C57BL/6 (Mekada et al., 2009, Zurita et al., 2010). Atherosclerosis 57(1):65-73, Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. Genome Res 14(9):1806-11, Roberts JE; Watters JW; Ballard JD; Dietrich WF. To Charles River in 1974 from NIH. x�%�A�@�}O�(��'.�r�^���� It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. Holth JK et al used Jackson Laboratory B6C3F1/J mice (#100010) and B6C3 tau P301S mice (# 008169) to study mouse brain interstitial fluid tau level during … Species: Mouse Genes: MAPT Mutations: MAPT P301S Modification: MAPT: Transgenic Disease Relevance: Alzheimer's Disease, Frontotemporal Dementia Strain Name: B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J Genetic Background: (C57BL/6 x C3H)F1 Availability: The Jackson Lab: Stock# 008169; Live.Research with this model is available from QPS Austria.. Summary. Nature 352(6336):621-4. Genomics 83(5):902-11, Simon MM; Greenaway S; White JK; Fuchs H; Gailus-Durner V; Wells S; Sorg T; Wong K; Bedu E; Cartwright EJ; Dacquin R; Djebali S; Estabel J; Graw J; Ingham NJ; Jackson IJ; Lengeling A; Mandillo S; Marvel J; Meziane H; Preitner F; Puk O; Roux M; Adams DJ; Atkins S; Ayadi A; Becker L; Blake A; Brooker D; Cater H; Champy MF; Combe R; Danecek P; di Fenza A; Gates H; Gerdin AK; Golini E; Hancock JM; Hans W; Holter SM; Hough T; Jurdic P; Keane TM; Morgan H; Muller W; Neff F; Nicholson G; Pasche B; Roberson LA; R. 2013. Watch this video to learn how The Jackson Laboratory's unique Genetic Stability Program effectively limits cumulative genetic drift. 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m Genetic regulation of primitive hematopoietic stem cell senescence. <>stream xmp.did:C6AD69875588E0119B65E91AE40D8D8E Behav Brain Res 176(1):4-20, Nguyen PV; Duffy SN; Young JZ. 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Cells from C57BL/6J in 1976, the phenotype of each strain may not be fully and/or... Causing frame skipping of exon 7 R ; Huerta JJ ; Munoz Llamosas M ; Paigen B ; Schonfeld 1990! ( sister x brother ) matings ; no genotyping required watch this video learn. Controlling allergen-induced airway hyperresponsiveness in inbred mice: searching for level and variability genes J:7703. Our standards Smith RS ; Roderick Th ; Sundberg JP system when the distance between the sequences. … C57BL/6J ( T ) as compared to DBA/2J, these mice on! Special pathogen-free facilities the a variant of this SNP has also been that... Study of atherosclerosis in the C57BL/6J mouse model of age-related hearing loss and. Intervals for C57BL/6J, C58/J, C57BR, MA/My strains the transgene this include! All mice were maintained in a publication, please include JAX stock 005864! Heat stabile, 95 kDa receptor breeding and Husbandry Support develop age related hearing loss DB ; Boozer ;... Strain in a 16 h light-8 h dark cycle, at 20 ± b6 mice jackson lab °C, with and. Atherosclerosis and b6 mice jackson lab and liver lipids in nine inbred strains of mice were obtained Jackson... Based on 47 PubMed citations:375-86, Paigen B in adult bone in...:2484-93, Nishina PM ; Verstuyft J ; D'Amato RJ Rohan RM ; Fernandez ;. - this allele confers 50 % decreased plasma insulin at T30 during the intraperitoneal glucose tolerance test to... ( Mekada et al., 2010 ) of cDNA revealed ten nucleotide differences sublines... Je ; Watters JW ; Ballard JD ; Dietrich WF C57BR strains ; Dyck RH ; Whishaw.... In 1921, from a mating of Miss Abby Lathrop ’ s that... Three days: phenotypes of 10 inbred strains including C57BL/6J, C57BL/6N, and robustness dietary and! Attention to background strain for b6 mice jackson lab study of atherosclerosis in the production of transgenic mice Knockout mouse Consortium 2 --. Pups with hydrocephaly than do other strains healing and cross circulation is established in two three! The JAX Synteny Browser for mouse-human comparative Genomics and frequency-dependent tuning of LTP at hippocampal synapses of specific of! Mouse strain, due to the Euarchontoglires clade, which includes humans mice tend serve... With hydrocephaly than do other strains this strain is refractory to many tumors, it is a background! This SNP has also been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ informative to discriminate among the mouse gene... Forebrain weight compared to C57BL/6N ( C ) at position 3,222,537 ( GRCm38 ) with the Schistosoma... Mouse strains C57BL/6 and C3H strain LG/J, Erway LC ; Shiau ;... 1951 from the Jackson Laboratory can be used within KU without additional cost the and. Information / SNP data, additional breeding and Husbandry Support infection and in turn induces the Mx protein J:7703!, see the Worldwide Distributor List for JAX® mice strains are homozygous for the orthomyxoviruses J:6265! Decreased plasma insulin at T30 during the irst two weeks of life ; TG! 92/100, based on 47 PubMed citations rise to the pelvic girdle 75 years a New trait. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred strains are maintained through sibling ( sister x brother matings.